4 seams fast ball

Is there any importance if the horseshoe is one side or the other when I place my two fingers on the ball?

depends on how big your hands. if you have big enough hands you can place it on either side because your fingers will be long enough to grip both seams but if your fingers are smaller you might want to grip it with the openned side of horse-shoe facinge left if you’re a righty. that’s the technical way to see it but just do what is comfortable.